Towards a Work Breakdown Structure for Net Centric System of Systems Engineering and Management

As the system engineering industry sees an increasing focus on the lifecycle development, acquisition, and sustainment of net-centric Systems of Systems (SoS), organizations find that current processes and tools need to evolve to handle the increased scope, scale, and complexity of these efforts. One such tool, the Work Breakdown Structure (WBS) is important in planning, monitoring, and re-focusing of program activities as requirements and goals of the program evolve. This paper provides an overview of the limitations of current standard WBSs with respect to SoS efforts and presents a proposed WBS structure that more adequately reflects the evolving processes and cross-organizational complexities

The sense of smell, its signalling pathways, and the dichotomy of cilia and microvilli in olfactory sensory cells

Smell is often regarded as an ancillary perception in primates, who seem so dominated by their sense of vision. In this paper, we will portray some aspects of the significance of olfaction to human life and speculate on what evolutionary factors contribute to keeping it alive. We then outline the functional architecture of olfactory sensory neurons and their signal transduction pathways, which are the primary detectors that render olfactory perception possible. Throughout the phylogenetic tree, olfactory neurons, at their apical tip, are either decorated with cilia or with microvilli. The significance of this dichotomy is unknown. It is generally assumed that mammalian olfactory neurons are of the ciliary type only. The existance of so-called olfactory microvillar cells in mammals, however, is well documented, but their nature remains unclear and their function orphaned. This paper discusses the possibility, that in the main olfactory epithelium of mammals ciliated and microvillar sensory cells exist concurrently. We review evidence related to this hypothesis and ask, what function olfactory microvillar cells might have and what signalling mechanisms they use

Impact of COVID-19 on cardiovascular testing in the United States versus the rest of the world

Objectives: This study sought to quantify and compare the decline in volumes of cardiovascular procedures between the United States and non-US institutions during the early phase of the coronavirus disease-2019 (COVID-19) pandemic. Background: The COVID-19 pandemic has disrupted the care of many non-COVID-19 illnesses. Reductions in diagnostic cardiovascular testing around the world have led to concerns over the implications of reduced testing for cardiovascular disease (CVD) morbidity and mortality. Methods: Data were submitted to the INCAPS-COVID (International Atomic Energy Agency Non-Invasive Cardiology Protocols Study of COVID-19), a multinational registry comprising 909 institutions in 108 countries (including 155 facilities in 40 U.S. states), assessing the impact of the COVID-19 pandemic on volumes of diagnostic cardiovascular procedures. Data were obtained for April 2020 and compared with volumes of baseline procedures from March 2019. We compared laboratory characteristics, practices, and procedure volumes between U.S. and non-U.S. facilities and between U.S. geographic regions and identified factors associated with volume reduction in the United States. Results: Reductions in the volumes of procedures in the United States were similar to those in non-U.S. facilities (68% vs. 63%, respectively; p = 0.237), although U.S. facilities reported greater reductions in invasive coronary angiography (69% vs. 53%, respectively; p < 0.001). Significantly more U.S. facilities reported increased use of telehealth and patient screening measures than non-U.S. facilities, such as temperature checks, symptom screenings, and COVID-19 testing. Reductions in volumes of procedures differed between U.S. regions, with larger declines observed in the Northeast (76%) and Midwest (74%) than in the South (62%) and West (44%). Prevalence of COVID-19, staff redeployments, outpatient centers, and urban centers were associated with greater reductions in volume in U.S. facilities in a multivariable analysis. Conclusions: We observed marked reductions in U.S. cardiovascular testing in the early phase of the pandemic and significant variability between U.S. regions. The association between reductions of volumes and COVID-19 prevalence in the United States highlighted the need for proactive efforts to maintain access to cardiovascular testing in areas most affected by outbreaks of COVID-19 infection

Best Practices

Current trends toward the transformation of warfare (and other large-scale competitive pursuits) into network-centric and knowledge-based systems of systems show great promise for competitive advantages over traditionally organized groups of largely independent components. However, these transformational systems of systems are critically dependent on the successful functioning of their computer software [1, 2]. This article summarizes the benefits provided by software for such transformational systems and identifies a top-10 list of risks and challenges that need to be resolved in developing and evolving software-intensive systems. It then briefly summarizes the Win-Win Spiral Model described in more detail in CrossTalk [3, 4], and shows how its application can be used to mitigate the top-10 software-intensive system risks and challenges. Software Benefits for Transformational Systems While simpler, tangible hardware configurations are easier to manage than softwareintensive system acquisitions and operations, pure hardware-based solutions cannot provide several key benefits that software can provide for complex transformational systems of systems. These include the following: • The need to accommodate many combinations of mission options. Trying to accommodate these in hardware leads to earlier freezing of optio

Ballroom A

Recent events in Afghanistan have convincingly demonstrated the value o